哪吒机器人提醒:

提醒:Journal of Biological Chemistry current issue
【标题】Ets2 in T-cell Development, Survival, and Apoptosis [Developmental Biology]
【摘要】interference of ras signaling deregulates thymocyte development in mouse models. however, the role of ets-2, a transcription factor that is phosphorylated on a critical threonine residue (thr-72) by the ras/mapk pathway in thymocyte development, has not been defined. transgenic mice overexpressing a phosphomutant ets-2 (t72a) in the thymus displayed reduced thymus size associated with a 60–80% reduction in thymocyte populations. the transgenic mice exhibited a 20-fold increase in a c-kit+ cd4+ c... (02-18 09:02)