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【标题】Adenosine kinase inhibition selectively promotes rodent and porcine islet {beta}-cell replication [Medical Sciences]
【摘要】diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro- and macrovascular disease. one therapeutic strategy is to amplify insulin-secretion capacity by increasing the number of the insulin-producing β cells without triggering a generalized proliferative response. here, we present the development of a small-molecule screening platform for the identification of molecules that increase β-cell replication. using t... (02-16 15:41)
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