Nature Reviews Drug Discovery

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
Nature Reviews Drug Discovery 7, 1001 (2008). doi:10.1038/nrd2637
Author: Avi Ashkenazi
Each day, the human body elimin...

Protein–protein Interactions: Getting rid of JNK
Nature Reviews Drug Discovery 7, 975 (2008). doi:10.1038/nrd2771
Author: Monica Hoyos Flight
Jun N-terminal kinases (JNKs) phosphorylate and activa...

Obesity: Repurposed agent shows weight-loss potential
Nature Reviews Drug Discovery 7, 978 (2008). doi:10.1038/nrd2772
Author: Man Tsuey Tse
A Phase II trial of tesofensine, an inhibitor of the pr...

Type 1 diabetes: Islet renovation
Nature Reviews Drug Discovery 7, 976 (2008). doi:10.1038/nrd2769
Author: Sarah Crunkhorn
T-cell-mediated autoimmune destruction of insulin-producing β cells of th...

The genetics of the p53 pathway, apoptosis and cancer therapy
Nature Reviews Drug Discovery 7, 979 (2008). doi:10.1038/nrd2656
Authors: Alexei Vazquez, Elisabeth E. Bond, Arnold J. Levine
& Gareth...

BCL-2 family antagonists for cancer therapy
Nature Reviews Drug Discovery 7, 989 (2008). doi:10.1038/nrd2658
Authors: Guillaume Lessene, Peter E. Czabotar
& Peter M. Colman
Overexpression of membe...

Targeting apoptosis: selected anticancer strategies
Nature Reviews Drug Discovery 7, 971 (2008). doi:10.1038/nrd2662
Author: Shane Storey
Selective modulation of the apoptotic machinery has been t...

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Nature Reviews Drug Discovery 7, 1013 (2008). doi:10.1038/nrd2755
Authors: Inki Kim, Wenjie Xu
& John C...

Apoptosis: a clinical perspective
Nature Reviews Drug Discovery 7, 959 (2008). doi:10.1038/nrd2756
Authors: Ernest C. Borden, Harriet Kluger
& John Crowley
Dissection of the signalling pathways me...

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways
Nature Reviews Drug Discovery 7, 1031 (2008). doi:10.1038/nrd2759
Authors: Anwesha Dey, Vinay Tergaonkar...